Metacam For Cats

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Metacam For Cats

But is it safe to give Metacam liquid orally to cats? In Europe, Australia and New Zealand, and now Canada the Metacam label says it is safe for use in cats. In the US and Canada, the only form of Metacam that is officially safe for use in cats is a one time dose of the injectable product. However, many vets will still prescribe Metacam for long term use in cats. This is called “off-label use” and is very common in veterinary medicine.
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Metacam For Cats

The primary variable to evaluate the efficacy of Metacam® Oral Suspension for Cats was the change from baseline of the Clinical Sum Score (CSS) calculated by adding the single scores of posture, lameness and pain on manipulation. Change from baseline was -4.3 in the Metacam® Oral Suspension for Cats group and -4.4 in the positive control group. For this primary variable, significant non-inferiority of Metacam® Oral Suspension for Cats in comparison to the positive control was shown and thus proved efficacy.
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Metacam For Cats

I do really believe that when Metacam is given appropriately, at the correct dosage, to a healthy cat the chances of developing kidney problems are extremely rare. But, it can happen. I have also noticed that in the US, the dose for a Metacam injection for cats is 0.3 mg/kg. In Canada it is 0.2 mg/kg. It may be that there are more issues with Metacam for cats in the US because of the higher recommended dose.
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Metacam For Cats

Dealing with Adverse Reactions to Metacam If you believe your cat has developed renal failure as a result of using Metacam, you should report this to the manufacturer. Boehringer Ingelheim Vetmedica, Inc. 2621 North Belt Highway St. Joseph, MO 64506-2002 1-800-325-9167 or 1-866-638-2226 Most cats who suffer renal failure as a result of using Metacam are suffering from acute renal failure (ARF) and their bloodwork may be extremely high, with creatinine often in the high teens. Do not give up hope! Acute renal failure is difficult to treat, but not impossible: an aggressive treatment plan should see those numbers dramatically reduce in most cases, so don’t opt for euthanasia immediately. A treatment program which includes 4-5 days of IV fluid therapy (hospitalisation), followed by 4-6 weeks of sub-Q fluids at home, is often recommended by the manufacturers, but talk to them and see what they suggest for your cat. I would also suggest that you ask the manufacturers to pay your veterinary costs – I know they have done this for some people, although they have not necessarily paid the full costs. You should also make a report to the Food & Drug Administration. Apparently the manufacturers are not obliged to report any cases of renal failure to the FDA because renal failure is already listed in the package insert as a possible side effect (see the link below). But I believe it is very important for the FDA to be fully aware of the scale of the problem. What to Watch For Disorientation Incoordination Decreased urine production Straining to urinate Loss of appetite Lethargy Vomiting Weakness Changes in water consumption and urination
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Metacam For Cats

My Dushka has just developed a urinary infection. The vet I saw this morning (not my regular one but a member of the practice) wants me to give her Metacam to relieve the pain. He knows I am against it and said that the last time I raised this they had a practice meeting to discuss it and did some research, which at least means they took me seriously. But their conclusion was that in Europe the Metacam for cats is at a lower dosage than the US version and has been demonstrated to be safe. He refused me any alternative, saying the Metacam is safer. I brought it home prior to doing some more research. Having read up a bit more, I will not give it to Dushka, who already has severe renal issues and is on kidney meds and diet, prescribed by this same vet 6 months ago! Faced with the alternatives of high risk AKF and 3 days of diminishing pain, I am afraid I have opted for the latter. jennyr, Jul 19, 2016
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My Dushka has just developed a urinary infection. The vet I saw this morning (not my regular one but a member of the practice) wants me to give her Metacam to relieve the pain. He knows I am against it and said that the last time I raised this they had a practice meeting to discuss it and did some research, which at least means they took me seriously. But their conclusion was that in Europe the Metacam for cats is at a lower dosage than the US version and has been demonstrated to be safe. He refused me any alternative, saying the Metacam is safer. I brought it home prior to doing some more research. Having read up a bit more, I will not give it to Dushka, who already has severe renal issues and is on kidney meds and diet, prescribed by this same vet 6 months ago! Faced with the alternatives of high risk AKF and 3 days of diminishing pain, I am afraid I have opted for the latter.
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Gosh.  What a timely and somewhat scary article.  My cat only vet recently prescribed oral Metacam for my tabby Archie,  He is receiving physical therapy for some spinal issues.  Metacam was recommended to help control the inflamation.  I didn't think much about it.  Since Metacam is not a steroid, I assumed the drug would be safe.  He loves taking it; in fact, on more than one occasion he has carried the box to me, suggesting he wanted a dosage (every other day).   Now I am concerned.  The box does not show the black label warning mentioned in the article, but the instructions (which I didn't read at the time) do say for dogs only.  I need to have a conversation with my vet.  The only warning I was given, was to make sure that he is eating and drinking, which he is. rickr, Feb 18, 2016
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Gosh.  What a timely and somewhat scary article.  My cat only vet recently prescribed oral Metacam for my tabby Archie,  He is receiving physical therapy for some spinal issues.  Metacam was recommended to help control the inflamation.  I didn't think much about it.  Since Metacam is not a steroid, I assumed the drug would be safe.  He loves taking it; in fact, on more than one occasion he has carried the box to me, suggesting he wanted a dosage (every other day).   Now I am concerned.  The box does not show the black label warning mentioned in the article, but the instructions (which I didn't read at the time) do say for dogs only.  I need to have a conversation with my vet.  The only warning I was given, was to make sure that he is eating and drinking, which he is.
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Safety Studies: Studies on cats receiving meloxicam have demonstrated much higher sensitivity to NSAIDs than dogs. Cats receiving a subcutaneous dose of Metacam 0.5% Injection at 0.3 mg/kg or 0.6 mg/kg, followed by the same dose orally with Metacam 1.5 mg/mL Oral Suspension for 8 additional days (4 cats per group) had decreased appetites, acute gastrointestinal and circulatory disorders after day 7. Necropsy (day 9) confirmed treatment-related pyloric/duodenal ulceration and secondary peritonitis.
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Despite what I have written above, I do now give Metacam injections to cats when I feel it is necessary. However, I use a dose of 0.1 mg/kg. The labelled dose in Canada is 0.2mg/kg and most of the cases where cats have reacted had the US recommended dose of 0.3 mg/kg. I also send some of my surgery patients home with a box of oral Metacam, that is now labelled for use in cats, for a maximum of three days. If an animal has an issue with their kidneys, or experienced low blood pressure during surgery then I will avoid any NSAIDS.
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Pharmacokinetics: When Metacam® Oral Suspension for Cats is given in a fasted state, the maximal plasma concentrations are obtained after approximately 3 hours. If the cat is in a fed state at the time of dosing, absorption may be slightly delayed. Approximately 97% of meloxicam is bound to plasma proteins. Meloxicam is predominately found in plasma and is also a major biliary excretion product whereas urine contains only traces of parent compound. Meloxicam is eliminated with a half life of approximately 24 hours. Seventy-nine percent of the recovered dose is eliminated in the faeces and 21% in the urine. All major metabolites have been shown to be pharmacologically inactive. Administration of an initial oral loading dose of 0.1 mg/kg, followed by repeated oral dosing with Metacam® Oral Suspension for Cats at 0.05 mg/kg resulted in the accumulation of meloxicam with time (over 2 to 7 days).
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Remember, the controversy that was discussed above is regarding the use of a Metacam Injection. I no longer give Metacam injections to cats, but I do prescribe it orally to some cats.
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In total, 120 cats (60 cats in each treatment group) were included in the study. Among the patients that completed the study, 54 cats were treated with Metacam® Oral Suspension for Cats at a dosage of 0.1 mg/kg once on the first day, followed by a dosage of 0.05 mg/kg once daily for the four following days, and 58 cats received the positive control drug at the approved dosage for 5 consecutive days.

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